NLGN4X

The information for this summary of NLGN4X-related syndrome comes from research publications. This is not meant to take the place of medical advice.

Click here for our full NLGN4X Gene Guide

The online Gene Guide includes more information about NLGN4X such as the chance of having another child with this condition, behavior and development concerns linked to NLGN4X-related syndrome or specialists to consider for people with this condition. Share this resource with family members or your clinical providers.

NLGN4X-related syndrome is also called autism susceptibility, X-linked 2 and intellectual developmental disorder, X-linked. For this webpage, we will be using the name NLGN4X-related syndrome to encompass the wide range of variants observed in the people identified.

What is NLGN4X-related Syndrome?

NLGN4X-related syndrome happens when there are changes in the NLGN4X gene. These changes can keep the gene from working as it should.

Key Role

The NLGN4X gene plays a key role in communication between brain cells. 

Symptoms

Because the NLGN4X gene is important for brain activity, many people who have NLGN4X-related syndrome have: 

  • Autism 
  • Intellectual disability 
  • Developmental delay 
  • Speaking impairment and motor speech disorder 
  • Repetitive behaviors 
  • Attention-deficit/hyperactivity disorder (ADHD) 
  • Motor tics

How many people have NLGN4X-related syndrome look?

As of 2024, over 20 people with NLGN4X-related syndrome have been reported in medical research. 

Learn more about the NLGN4X gene and connect with other Simons Searchlight families with the resources below:

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Support Resources

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Research Article Summaries

We currently do not have any articles summaries for NLGN4X, but we periodically add resources to our website as they become available.

As we learn more from children who have these gene changes, we expect this list of resources and information to grow.

Full versions of published research articles can be found on PubMed. PubMed is a National Institutes of Health (NIH) online database that is free. It has a collection of both medical and scientific research articles. A PubMed search for NLGN4X articles can be found here.

You can also visit SFARI’s website to see information written for researchers about this gene. SFARIgene: NLGN4X

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Research Opportunities

Simons Searchlight

Help the Simons Searchlight team learn more about NLGN4X genetic changes by joining research! You can learn more about the project and sign up here.

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Family Stories

We do not currently have any stories from NLGN4X families.

Click here to share your family’s story!