MEIS2

The information for this summary of MEIS2-related syndrome comes from research publications. This is not meant to take the place of medical advice.

Click here for our full MEIS2 Gene Guide

The online Gene Guide includes more information about MEIS2 such as the chance of having another child with this condition, behavior and development concerns linked to MEIS2-related syndrome or specialists to consider for people with this condition. Share this resource with family members or your clinical providers.

What is MEIS2-related syndrome?

MEIS2-related syndrome happens when there are changes in the MEIS2 gene. These changes can keep the gene from working as it should.

Key Role

The MEIS2 gene plays a key role in the development of the brain and the heart. 

Symptoms

Because the MEIS2 gene is important for brain activity, many people who have MEIS2-related syndrome have: 

  • Cleft palate, which is an opening or split in the upper lip or roof of the mouth that occurs before birth 
  • Developmental delay 
  • Intellectual disability 
  • Behavioral issues 
  • Changes in the heart structure 
  • Feeding issues

How many people have MEIS2-related syndrome?

As of 2024, over 49 people with MEIS2-related syndrome have been identified in a medical clinic. 

Learn more about the MEIS2 gene and connect with other Simons Searchlight families with the resources below:

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Support Resources

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GeneReviews

GeneReviews are a great resource to bring to your child’s clinicians. These publications provide a summary of current research on genetic conditions and information on ongoing care.

There is currently no GeneReviews for MEIS2.

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Research Article Summaries

We currently do not have any article summaries for MEIS2, but we add resources to our website as they become available.

The information available about MEIS2 is limited, and families and doctors share a critical need for more information. As we learn more from children who have this gene change, we expect our list of resources and information to grow.

Full versions of published research articles can be found on PubMed. PubMed is a National Institutes of Health (NIH) online database that is free. It has a collection of both medical and scientific research articles. A PubMed search for MEIS2 articles can be found here.

You can also visit the Simons Foundation’s SFARI Gene website to see information for researchers about this gene.

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Research Opportunities

Simons Searchlight

Help the Simons Searchlight team learn more about MEIS2 genetic changes by taking part in our research. You can learn more about the project and sign up here.

External Research Opportunity: FaceMatch

FaceMatch is a platform that helps parents and doctors contribute to an international secure image database of both undiagnosed and diagnosed children across the globe. *This study is not affiliated with Simons Searchlight. Learn more about FaceMatch.

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Family Stories

We do not currently have any stories from MEIS2 families.

Click here to share your family’s story!