POGZ
The information for this summary of POGZ-related syndrome comes from research publications. This is not meant to take the place of medical advice.
Click here for our full POGZ Gene Guide
The online Gene Guide includes more information about POGZ such as the chance of having another child with this condition, behavior and development concerns linked to POGZ-related syndrome or specialists to consider for people with this condition. Share this resource with family members or your clinical providers.
POGZ-related syndrome is also called White-Sutton syndrome. For this webpage, we will be using the name POGZ-related syndrome to encompass the wide range of variants observed in the people identified.
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What is POGZ-related syndrome?
POGZ-related syndrome happens when there are changes in the POGZ gene. These changes can keep the gene from working as it should.
Key Role
The POGZ gene plays a role in brain development.
Symptoms
Because the POGZ gene is important in brain development and function, many people who have POGZ-related syndrome have:
- Feeding difficulties
- Lower than average muscle tone
- Smaller than average head size
- Sleeping issues
- Developmental delay
- Intellectual disability
- Features of autism
- Self-injurious behavior
- Vision issues
How many people have POGZ-related syndrome?
As of 2024, at least 162 people with POGZ-related syndrome have been identified in a medical clinic.
Support Resources
- Simons Searchlight Community – POGZ Facebook Group
- White Sutton Syndrome Foundation – https://whitesutton.org/
GeneReviews
GeneReviews are a great resource to bring to your child’s clinicians. These publications provide a summary of current research on genetic conditions and information on ongoing care.
Click here for the POGZ GeneReview
Research Articles and References
Below, we have summarized research articles about changes in the POGZ gene. We hope you find this information helpful.
The information available about POGZ is limited, and families and doctors share a critical need for more information. As we learn more from children who have a change in this gene, we expect this list of resources and information to grow.
Full versions of published research articles can be found on PubMed. PubMed is a National Institutes of Health (NIH) online database that is free. It has a collection of both medical and scientific research articles. A PubMed search for POGZ articles can be found here.
You can also visit the Simons Foundation’s SFARI Gene website to see information for researchers about this gene.
Research Opportunities
Simons Searchlight
Help the Simons Searchlight team learn more about POGZ genetic changes by taking part in our research. You can learn more about the project and sign up here.